Asthma is a chronic airway disease, which affects more than 300 million people. The
pathogenesis of asthma exhibits marked heterogeneity with many phenotypes defining …

The cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

The BAFF system plays a key role in the development of autoimmunity, especially in
systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly …

Background Pruritus is a cardinal symptom of atopic dermatitis, and an increased cutaneous
sensory network is thought to contribute to pruritus. Although the immune cell–IL-31–neuron …

Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family
which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of …

In recent years, the published literature has suggested the key involvement of the cytokine
interleukin-31 (IL-31) in the symptomatology of pruritus, and both IL-31 and its receptor have …

Systemic sclerosis (SSc) is a chronic multisystem disorder characterized by fibrosis and
autoimmunity. Interleukin (IL)-31 has been implicated in fibrosis and T helper (Th) 2 immune …

Pruritus represents one of the most common symptoms in dermatology and general
medicine. Chronic pruritus severely impairs the quality of life of affected patients. During the …

Interleukin-31, produced mainly by activated CD4+ T cells, is a newly discovered member of
the gp130/IL-6 cytokine family. Unlike all the other family members, IL-31 does not engage …