Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Integrins are cell adhesion and signalling proteins crucial to a wide range of biological
functions. Effective marketed treatments have successfully targeted integrins αIIbβ3 …

A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential
consequences on the cardiovascular health of millions of people who survive infection …

Vascular endothelial cells (ECs) form a critical interface between blood and tissues that
maintains whole-body homeostasis. In COVID-19, disruption of the EC barrier results in …

To date, no effective vaccines or therapies are available against the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), the causative pandemic agent of the coronavirus …

SARS-CoV-2 is a novel coronavirus that severely affects the respiratory system, is the cause
of the COVID-19 pandemic, and is projected to result in the deaths of 2 million people …

Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

In the broad range of human diseases, thrombo-inflammation appears as a clinical
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …

Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is broadly accepted that SARS …

Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …