The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

The implantation of the blastocyst and early development of the placenta are crucial for the
success of implantation and pregnancy. However, the formative stages of human placental …

Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that
build the conceptus, yet how to capture this property in vitro remains incompletely …

GATA3 is a transcription factor important in the differentiation of breast epithelia, urothelia,
and subsets of T lymphocytes. It has been suggested to be useful in the evaluation of …

Three distinct cell types are present within the 64-cell stage mouse blastocyst. We have
investigated cellular development up to this stage using single-cell expression analysis of …

Integrative analysis of multi-omics layers at single cell level is critical for accurate dissection
of cell-to-cell variation within certain cell populations. Here we report scCAT-seq, a …

The mouse blastocyst and stem cells derived from its tissue lineages provide a unique
genetic system for examining the establishment and loss of pluripotency. The transcription …

The mouse embryo undergoes compaction at the 8-cell stage, and its transition to 16 cells
generates polarity such that the outer apical cells are trophectoderm (TE) precursors and the …

The trophectoderm (TE) and inner cell mass (ICM) are committed and marked by reciprocal
expression of Cdx2 and Oct4 in mouse late blastocysts. We find that the TE is not committed …

To elucidate the molecular basis of BMP4-induced differentiation of human pluripotent stem
cells (PSCs) toward progeny with trophectoderm characteristics, we produced transcriptome …