Angiogenesis, the formation of new blood vessels from preexisting one, represents a critical
process for oxygen and nutrient supply to proliferating cells, therefore promoting tumor …

Cardiovascular diseases (CVDs) are a group of disorders that affect the heart and blood
vessels. Due to their multifactorial nature and wide variation, CVDs are the leading cause of …

Non-communicable diseases (NCDs) are medical conditions that, by definition, are non-
infectious and non-transmissible among people. Much of current NCDs are generally due to …

The dynamic tyrosination-detyrosination cycle of α-tubulin regulates microtubule functions.
Perturbation of this cycle impairs mitosis, neural physiology, and cardiomyocyte contraction …

Hypoxia is one of the critical stressors encountered by various cells of the human body
under diverse pathophysiologic conditions including cancer and has profound impacts on …

Long non-coding (lnc) RNAs, once considered as junk and useless, are now broadly
recognized to have major functions in the cell. LncRNAs are defined as non-coding RNAs of …

Internal ribosome entry sites (IRESs) drive translation initiation during stress. In response to
hypoxia,(lymph) angiogenic factors responsible for tissue revascularization in ischemic …

The Western blot is widely used in the study of protein biochemistry, but it is notoriously
labor-intensive, and it is limited in its reproducibility and quantification, among many other …

Adult cardiac hypoxia as a crucial pathogenesis factor can induce detrimental effects on
cardiac injury and dysfunction. The global transcriptome and translatome reflecting the …

Hypoxia induces profound modifications in the gene expression program of eukaryotic cells
due to lowered ATP supply resulting from the blockade of oxidative phosphorylation. One …