During recent years, it has become clear that polymorphonuclear neutrophils are remarkably
versatile cells, whose functions go far beyond phagocytosis and killing. In fact, besides …

In hepatic schistosomiasis, pathology arises when schistosome eggs become lodged in the
host liver, evoking an interleukin 4 (IL-4)-and IL-13-mediated dominant CD4+ Th2 immune …

Hepatic fibrosis is a common pathology in various liver diseases. Hepatic stellate cells
(HSCs) are the main cell type responsible for collagen deposition and fibrosis formation in …

Neutrophils are the key players in the innate immune system, being weaponized with
numerous strategies to eliminate pathogens. The production of extracellular traps is one of …

Neutrophils are the most abundant leukocyte in humans and they are among the first white
cells recruited to infected tissues. These leukocytes are essential for the innate immune …

MicroRNAs (miRNAs) play a variety of roles in diverse biological processes at the post-
transcriptional regulatory level. Although numerous miRNAs have been identified in …

Schistosomiasis is the most important helminth disease in the world from a public health
perspective. S mansoni and S japonicum account for the majority of global intestinal …

Cryptosporidium parvum causes a zoonotic infection with worldwide distribution. Besides
humans, cryptosporidiosis affects a wide range of animals leading to significant economic …

Neutrophil extracellular traps (NETs) are DNA fibers associated with histones, enzymes from
neutrophil granules and anti-microbial peptides. NETs are released in a process …

Schistosomiasis is an important neglected tropical disease. Interactions between the host
immune system and schistosomes are complex. Neutrophils contribute to clearance of large …