Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …

Extracellular signals are often transduced by dynamic signaling complexes ("
signalosomes") assembled by oligomerizing hub proteins following their recruitment to …

In the Wnt–β-catenin pathway, Wnt binding to Frizzled (Fzd) and LRP5 or LRP6 (LRP5/6) co-
receptors inhibits the degradation of the transcriptional coactivator β-catenin by recruiting …

Summary β-Catenin-dependent WNT signal transduction governs development, tissue
homeostasis, and a vast array of human diseases. Signal propagation through a WNT …

In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or
HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS …

Ubiquitination serves as a critical signal in the host immune response to infection. Many
pathogens have evolved strategies to exploit the ubiquitin (Ub) system to promote their own …

Phosphoinositides account for only a small proportion of cellular phospholipids, but have
long been known to play an important role in diverse cellular processes, such as cell …

Cytoplasmic phosphoinositides (PI) are critical regulators of the membrane–cytosol interface
that control a myriad of cellular functions despite their low abundance among phospholipids …