The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7
W Chen, X Wu, J Hu, X Liu, Z Guo, J Wu… - Cardiovascular …, 2024 - Springer
Atherosclerosis is one of the leading causes of death worldwide. miR-26 is a potential
biomarker of atherosclerosis. Standardized diagnostic tests for miR-26 (MIR26-DX) have …
biomarker of atherosclerosis. Standardized diagnostic tests for miR-26 (MIR26-DX) have …
Unlocking the mysteries of VLDL: exploring its production, intracellular trafficking, and metabolism as therapeutic targets
Reducing circulating lipid levels is the centerpiece of strategies for preventing and treating
atherosclerotic cardiovascular disease (ASCVD). Despite many available lipid-lowering …
atherosclerotic cardiovascular disease (ASCVD). Despite many available lipid-lowering …
Impact of Bmal1 rescue and time-restricted feeding on liver and muscle proteomes during the active phase in mice
Molecular clocks and daily feeding cycles support metabolism in peripheral tissues.
Although the roles of local clocks and feeding are well defined at the transcriptional level …
Although the roles of local clocks and feeding are well defined at the transcriptional level …
Gain-of-function variants in lipid genes enhance biological insight and point toward therapeutic opportunities
S Stankov, C Vitali, DJ Rader - Circulation, 2022 - Am Heart Assoc
Dyslipidemia is associated with atherosclerotic cardiovascular disease (ASCVD), the
leading cause of death worldwide. 1 Plasma levels of low-density lipoprotein cholesterol …
leading cause of death worldwide. 1 Plasma levels of low-density lipoprotein cholesterol …
LIPC variant in combined hypocholesterolaemia
GB Lim - Nature Reviews Cardiology, 2022 - nature.com
Using next-generation sequencing, researchers have discovered a dominant, gain-of-
function variant in LIPC that underlies the combined hypocholesterolaemia observed in four …
function variant in LIPC that underlies the combined hypocholesterolaemia observed in four …
[PDF][PDF] APOC3 and ABCA1 variants in unusual combined hypolipidaemia showing premature peripheral vascular disease.
Z Pos, M Khedr, J Radvanszky… - Bratislava Medical …, 2023 - researchgate.net
BACKGROUND: Familial combined hypolipidaemia is a condition characterised by very low
concentrations of circulating very-low-density lipoprotein (VLDL), low-density lipoprotein …
concentrations of circulating very-low-density lipoprotein (VLDL), low-density lipoprotein …
Familial Hypercholesterolemia
F Siqin, T Muyun, WU Wei, Z Shuyang - Journal of Rare Diseases, 2023 - jrd.chard.org.cn
Familial hypercholesterolemia (FH) is a group of autosomal co-dominant genetic diseases
mainly characterized by abnormal low-density lipoprotein related metabolism. It is one of the …
mainly characterized by abnormal low-density lipoprotein related metabolism. It is one of the …