[HTML][HTML] Approaches to preventative and therapeutic HIV vaccines
GE Gray, F Laher, E Lazarus, B Ensoli… - Current opinion in virology, 2016 - Elsevier
Highlights•Non-efficacious preventative vaccines: gp120, Ad5 vector, DNA/Ad5.•Partially-
efficacious preventative vaccine: ALVAC-HIV/AIDSVAX® B/E gp120.•Clade C ALVAC/gp120 …
efficacious preventative vaccine: ALVAC-HIV/AIDSVAX® B/E gp120.•Clade C ALVAC/gp120 …
HIV-associated immune activation: from bench to bedside
HIV infection is associated with a state of chronic, generalized immune activation that has
been shown in many studies to be a key predictor of progression to AIDS. Consistent with …
been shown in many studies to be a key predictor of progression to AIDS. Consistent with …
Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein
Chronic immune activation is a major complication of antiretroviral therapy (ART) for HIV
infection and can cause a devastating immune reconstitution inflammatory syndrome (IRIS) …
infection and can cause a devastating immune reconstitution inflammatory syndrome (IRIS) …
Synaptic dysfunction in the hippocampus accompanies learning and memory deficits in human immunodeficiency virus type-1 Tat transgenic mice
S Fitting, BM Ignatowska-Jankowska, C Bull… - Biological …, 2013 - Elsevier
BACKGROUND: Human immunodeficiency virus (HIV) associated neurocognitive disorders
(HAND), including memory dysfunction, continue to be a major clinical manifestation of HIV …
(HAND), including memory dysfunction, continue to be a major clinical manifestation of HIV …
[HTML][HTML] Cellular stress responses and dysfunctional Mitochondrial–cellular senescence, and therapeutics in chronic respiratory diseases
The abnormal inflammatory responses due to the lung tissue damage and ineffective
repair/resolution in response to the inhaled toxicants result in the pathological changes …
repair/resolution in response to the inhaled toxicants result in the pathological changes …
Challenges in HIV vaccine research for treatment and prevention
B Ensoli, A Cafaro, P Monini, S Marcotullio… - Frontiers in …, 2014 - frontiersin.org
Many attempts have been made or are ongoing for HIV prevention and HIV cure. Many
successes are in the list, particularly for HIV drugs, recently proposed also for prevention …
successes are in the list, particularly for HIV drugs, recently proposed also for prevention …
Aptamers in HIV research diagnosis and therapy
J Bala, S Chinnapaiyan, RK Dutta, H Unwalla - RNA biology, 2018 - Taylor & Francis
Aptamers are high affinity single-stranded nucleic acid or protein ligands which exhibit
specificity and avidity comparable to, or exceeding that of antibodies and can be generated …
specificity and avidity comparable to, or exceeding that of antibodies and can be generated …
Immune reconstitution inflammatory syndrome and the central nervous system
The risk for CNS-IRIS can be decreased by starting ART early in the course of the illness or
by reducing antigenic burden with antimicrobial treatment for opportunistic infections prior to …
by reducing antigenic burden with antimicrobial treatment for opportunistic infections prior to …
HIV-1 Tat immunization restores immune homeostasis and attacks the HAART-resistant blood HIV DNA: results of a randomized phase II exploratory clinical trial
F Ensoli, A Cafaro, A Casabianca, A Tripiciano… - Retrovirology, 2015 - Springer
Background The phase II multicenter, randomized, open label, therapeutic trial (ISS T-002,
Clinicaltrials. gov NCT00751595) was aimed at evaluating the immunogenicity and the …
Clinicaltrials. gov NCT00751595) was aimed at evaluating the immunogenicity and the …
Therapeutic vaccines against HIV infection
F García, A León, JM Gatell, M Plana… - Human vaccines & …, 2012 - Taylor & Francis
Resistance to medication, adverse effects in the medium-to-long-term and cost all place
important limitations on lifelong adherence to combined antiretroviral therapy (cART). In this …
important limitations on lifelong adherence to combined antiretroviral therapy (cART). In this …