Specific expression and functions of circular RNAs
In recent years, circular RNAs (circRNAs), a new class of RNA molecules characterized by
their covalently closed circular structure, have become a new research paradigm in RNA …
their covalently closed circular structure, have become a new research paradigm in RNA …
The molecular basis of translation initiation and its regulation in eukaryotes
J Brito Querido, I Díaz-López… - Nature Reviews Molecular …, 2024 - nature.com
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …
regulation of gene expression has been studied for several decades, it has been clear over …
The plasticity of mRNA translation during cancer progression and therapy resistance
L Fabbri, A Chakraborty, C Robert, S Vagner - Nature Reviews Cancer, 2021 - nature.com
Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …
Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA
P Wu, Y Mo, M Peng, T Tang, Y Zhong, X Deng… - Molecular cancer, 2020 - Springer
Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …
[HTML][HTML] Innate immune evasion by human respiratory RNA viruses
M Kikkert - Journal of innate immunity, 2020 - karger.com
The impact of respiratory virus infections on the health of children and adults can be very
significant. Yet, in contrast to most other childhood infections as well as other viral and …
significant. Yet, in contrast to most other childhood infections as well as other viral and …
[HTML][HTML] Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis
Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still
largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is …
largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is …
Dynamic m6A mRNA methylation directs translational control of heat shock response
The most abundant mRNA post-transcriptional modification is N 6-methyladenosine (m6A),
which has broad roles in RNA biology,,,,. In mammalian cells, the asymmetric distribution of …
which has broad roles in RNA biology,,,,. In mammalian cells, the asymmetric distribution of …
Clinical delivery of circular RNA: lessons learned from RNA drug development
Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules,
which play diverse roles in regulating biological processes and disease states. The …
which play diverse roles in regulating biological processes and disease states. The …
Circular RNA translation, a path to hidden proteome
Functional proteins in the cell are translated from the messenger RNA (mRNA) molecules,
constituting less than 5% of the cellular transcriptome. The majority of the RNA molecules in …
constituting less than 5% of the cellular transcriptome. The majority of the RNA molecules in …
Protein synthesis initiation in eukaryotic cells
WC Merrick, GD Pavitt - Cold Spring Harbor perspectives …, 2018 - cshperspectives.cshlp.org
This review summarizes our current understanding of the major pathway for the initiation
phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe …
phase of protein synthesis in eukaryotic cells, with a focus on recent advances. We describe …