Post-traumatic osteoarthritis: from mouse models to clinical trials

CB Little, DJ Hunter - Nature Reviews Rheumatology, 2013 - nature.com
Osteoarthritis (OA), the most common of all arthropathies, is a leading cause of disability and
has a large (and growing) worldwide socioeconomic cost. Despite its burgeoning …

Ankle osteoarthritis: etiology, diagnostics, and classification

A Barg, GI Pagenstert, T Hügle, M Gloyer… - Foot and ankle …, 2013 - foot.theclinics.com
Osteoarthritis (OA) as a debilitating chronic disease is a growing problem in health care. 1–3
Approximately 1% of the world's adult population is affected by ankle OA, which results in …

The roles of mechanical stresses in the pathogenesis of osteoarthritis: implications for treatment of joint injuries

JA Buckwalter, DD Anderson, TD Brown… - Cartilage, 2013 - journals.sagepub.com
Excessive joint surface loadings, either single (acute impact event) or repetitive (cumulative
contact stress), can cause the clinical syndrome of osteoarthritis (OA). Despite advances in …

Post‐traumatic osteoarthritis of the ankle: a distinct clinical entity requiring new research approaches

ML Delco, JG Kennedy, LJ Bonassar… - Journal of Orthopaedic …, 2017 - Wiley Online Library
The diagnosis of ankle osteoarthritis (OA) is increasing as a result of advancements in non‐
invasive imaging modalities such as magnetic resonance imaging, improved arthroscopic …

Post-traumatic osteoarthritis: a review of pathogenic mechanisms and novel targets for mitigation

JE Dilley, MA Bello, N Roman, T McKinley, U Sankar - Bone Reports, 2023 - Elsevier
Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury and accounts for
12% of all osteoarthritis. These injuries, often of the lower extremity joints, occur due to …

Posttraumatic osteoarthritis caused by battlefield injuries: the primary source of disability in warriors

JC Rivera, JC Wenke, JA Buckwalter… - JAAOS-Journal of the …, 2012 - journals.lww.com
Abstract The Army Physical Evaluation Board results for wounded warriors from a previously
described cohort were reviewed to identify permanently disabling conditions and whether …

Objective Structured Assessments of Technical Skills (OSATS) does not assess the quality of the surgical result effectively

DD Anderson, S Long, GW Thomas… - … and Related Research®, 2016 - Springer
Background Performance assessment in skills training is ideally based on objective,
reliable, and clinically relevant indicators of success. The Objective Structured Assessment …

Statistical shape modeling of the talocrural joint using a hybrid multi-articulation joint approach

AL Lenz, N Krähenbühl, AC Peterson, RJ Lisonbee… - Scientific Reports, 2021 - nature.com
Historically, conventional radiographs have been the primary tool to morphometrically
evaluate the talocrural joint, which is comprised of the distal tibia, distal fibula, and proximal …

Ankle joint contact loads and displacement with progressive syndesmotic injury

KJ Hunt, Y Goeb, AW Behn… - Foot & Ankle …, 2015 - journals.sagepub.com
Background: Ligamentous injuries to the distal tibiofibular syndesmosis are predictive of
long-term ankle dysfunction. Mild and moderate syndesmotic injuries are difficult to stratify …

Validation of a personalized ligament-constraining discrete element framework for computing ankle joint contact mechanics

M Peiffer, K Duquesne, A Van Oevelen… - Computer Methods and …, 2023 - Elsevier
Abstract Background and Objective Computer simulations of joint contact mechanics have
great merit to improve our current understanding of articular ankle pathology. Owed to its …