AI-powered therapeutic target discovery
Disease modeling and target identification are the most crucial initial steps in drug
discovery, and influence the probability of success at every step of drug development …
discovery, and influence the probability of success at every step of drug development …
Molecular quantitative trait loci
Understanding functional effects of genetic variants is one of the key challenges in human
genetics, as much of disease-associated variation is located in non-coding regions with …
genetics, as much of disease-associated variation is located in non-coding regions with …
Systematic differences in discovery of genetic effects on gene expression and complex traits
Most signals in genome-wide association studies (GWAS) of complex traits implicate
noncoding genetic variants with putative gene regulatory effects. However, currently …
noncoding genetic variants with putative gene regulatory effects. However, currently …
Current challenges in understanding the role of enhancers in disease
Enhancers play a central role in the spatiotemporal control of gene expression and tend to
work in a cell-type-specific manner. In addition, they are suggested to be major contributors …
work in a cell-type-specific manner. In addition, they are suggested to be major contributors …
Limited overlap of eQTLs and GWAS hits due to systematic differences in discovery
Most signals in genome-wide association studies (GWAS) of complex traits point to
noncoding genetic variants with putative gene regulatory effects. However, currently …
noncoding genetic variants with putative gene regulatory effects. However, currently …
GWAS Atlas: an updated knowledgebase integrating more curated associations in plants and animals
X Liu, D Tian, C Li, B Tang, Z Wang… - Nucleic Acids …, 2023 - academic.oup.com
Abstract GWAS Atlas (https://ngdc. cncb. ac. cn/gwas/) is a manually curated resource of
genome-wide genotype-to-phenotype associations for a wide range of species. Here, we …
genome-wide genotype-to-phenotype associations for a wide range of species. Here, we …
Genetics of multiple sclerosis: lessons from polygenicity
A Goris, M Vandebergh, JL McCauley… - The Lancet …, 2022 - thelancet.com
Large-scale mapping studies have identified 236 independent genetic variants associated
with an increased risk of multiple sclerosis. However, none of these variants are found …
with an increased risk of multiple sclerosis. However, none of these variants are found …
Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis
M Takaoka, X Zhao, HY Lim, CG Magnussen, O Ang… - Nature, 2024 - nature.com
Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD).
Risk of cardiovascular events depends on cumulative lifetime exposure to low-density …
Risk of cardiovascular events depends on cumulative lifetime exposure to low-density …
Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders
Alternative polyadenylation (APA) plays an essential role in brain development; however,
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
current transcriptome-wide association studies (TWAS) largely overlook APA in nominating …
Transcriptome-and proteome-wide association studies nominate determinants of kidney function and damage
Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …