Intermolecular interactions involving aromatic rings are key processes in both chemical and
biological recognition. Their understanding is essential for rational drug design and lead …

Analysis of neighboring aromatic groups in four biphenyl peptides or peptide analogs and
34 proteins reveals a specific aromatic-aromatic interaction. Aromatic pairs (< 7 Å between …

The self-association of proteins into symmetric complexes is ubiquitous in all kingdoms of
life,,,,,. Symmetric complexes possess unique geometric and functional properties, but their …

A new class of protein tyrosine kinase inhibitors was identified that is based on an oxindole
core (indolinones). Two compounds from this class inhibited the kinase activity of fibroblast …

Geometric analysis of 33 refined high‐resolution protein crystal structures (2 Å or higher)
demonstrates that side‐chain amino groups interact with aromatic side chains. Positively …

Advances in molecular biology have had a dramatic impact on the drug discovery process.
1, 2 The ability to produce recombinant proteins of biological significance has greatly …

The ability of aromatic rings to act as acceptors in hydrogen bonds has been demonstrated
extensively both by experimental and by theoretical means. Countless examples of D …

Publisher Summary This chapter reviews the subject of noncovalent interactions in proteins
with particular emphasis on the so-called weakly polar interactions. The chapter discusses …

We have analyzed the structure of the interface between VL and VH domains in three
immunoglobulin fragments: Fab KOL, Fab NEW and Fab MCPC 603. About 1800 Å 2 of …

Thrombin is a multifunctional serine proteinase that plays a key role in coagulation while
exhibiting several other key cellular bioregulatory functions. The X-ray crystal structure of …