Antioxidant system and endoplasmic reticulum stress in cataracts

X Zhang, B Liu, K Lal, H Liu, M Tran, M Zhou… - Cellular and molecular …, 2023 - Springer
The primary underlying contributor for cataract, a leading cause of vision impairment and
blindness worldwide, is oxidative stress. Oxidative stress triggers protein damage, cell …

Genomics of human fibrotic diseases: disordered wound healing response

RC Stone, V Chen, J Burgess, S Pannu… - International journal of …, 2020 - mdpi.com
Fibrotic disease, which is implicated in almost half of all deaths worldwide, is the result of an
uncontrolled wound healing response to injury in which tissue is replaced by deposition of …

[HTML][HTML] Renal inflamm-aging provokes intra-graft inflammation following experimental kidney transplantation

A He, A Sarwar, LML Thole, J Siegle, A Sattler… - American Journal of …, 2022 - Elsevier
Donor age is a major risk factor for allograft outcome in kidney transplantation. The
underlying cellular mechanisms and the recipient's immune response within an aged …

DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation

R Nakamichi, A Hishikawa, S Chikuma, A Yoshimura… - Cell reports, 2023 - cell.com
Recent epigenome-wide studies suggest an association between blood DNA methylation
and kidney function. However, the pathological importance remains unclear. Here, we show …

DNMT3a negatively regulates PTEN to activate the PI3K/AKT pathway to aggravate renal fibrosis

T Hu, F Chen, D Chen, H Liang - Cellular Signalling, 2022 - Elsevier
Background Renal fibrosis has become one of the major diseases threatening global public
health and harming human life and health. PTEN methylation plays an important role in …

Recent advances in epigenetics of age-related kidney diseases

F Liu, J Chen, Z Li, X Meng - Genes, 2022 - mdpi.com
Renal aging has attracted increasing attention in today's aging society, as elderly people
with advanced age are more susceptible to various kidney disorders such as acute kidney …

DNA methylation-and telomere-based biological age estimation as markers of biological aging in donors kidneys

S Pavanello, M Campisi, P Rigotti, MD Bello… - Frontiers in …, 2022 - frontiersin.org
The biological age of an organ may represent a valuable tool for assessing its quality,
especially in the elder. We examined the biological age of the kidneys [right (RK) and left …

Ten-eleven translocation methyl-cytosine dioxygenase 2 deficiency exacerbates renal ischemia-reperfusion injury

H Yan, L Tan, Y Liu, N Huang, J Cang, H Wang - Clinical Epigenetics, 2020 - Springer
Abstract Background Ten-eleven translocation (Tet) methyl-cytosine dioxygenases
(including Tet1/2/3)-mediated 5mC oxidation and DNA demethylation play important roles in …

Hypermethylation and suppression of microRNA219a-2 activates the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis

Q Wei, X Xiao, E Huo, C Guo, X Zhou, X Hu, C Dong… - Molecular Therapy, 2024 - cell.com
Epigenetic regulations, such as DNA methylation and microRNAs, play an important role in
renal fibrosis. Here, we report the regulation of microRNA219a-2 by DNA methylation in …

DNA methylation in peripheral blood is associated with renal aging and renal function decline: a national community study

PL Yang, TS Lai, YH Chou, LC Lai, SL Lin, YM Chen - Clinical Epigenetics, 2024 - Springer
Background Older patients are at risk for acute kidney injury and chronic kidney disease.
Age-related increases in DNA methylation at CpG islands have been linked to aging-related …