The primary underlying contributor for cataract, a leading cause of vision impairment and
blindness worldwide, is oxidative stress. Oxidative stress triggers protein damage, cell …

Fibrotic disease, which is implicated in almost half of all deaths worldwide, is the result of an
uncontrolled wound healing response to injury in which tissue is replaced by deposition of …

Donor age is a major risk factor for allograft outcome in kidney transplantation. The
underlying cellular mechanisms and the recipient's immune response within an aged …

Recent epigenome-wide studies suggest an association between blood DNA methylation
and kidney function. However, the pathological importance remains unclear. Here, we show …

Background Renal fibrosis has become one of the major diseases threatening global public
health and harming human life and health. PTEN methylation plays an important role in …

Renal aging has attracted increasing attention in today's aging society, as elderly people
with advanced age are more susceptible to various kidney disorders such as acute kidney …

The biological age of an organ may represent a valuable tool for assessing its quality,
especially in the elder. We examined the biological age of the kidneys [right (RK) and left …

Abstract Background Ten-eleven translocation (Tet) methyl-cytosine dioxygenases
(including Tet1/2/3)-mediated 5mC oxidation and DNA demethylation play important roles in …

Epigenetic regulations, such as DNA methylation and microRNAs, play an important role in
renal fibrosis. Here, we report the regulation of microRNA219a-2 by DNA methylation in …

Background Older patients are at risk for acute kidney injury and chronic kidney disease.
Age-related increases in DNA methylation at CpG islands have been linked to aging-related …