Since the first high-resolution structure of the nucleosome was reported in 1997, the
available information on chromatin structure has increased very rapidly. Here, we review …

Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …

The cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) senses
invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy, and …

Mobile transposable elements (TEs) not only participate in genome evolution but also
threaten genome integrity. In healthy cells, TEs that encode all of the components that are …

Genomic DNA forms chromatin, in which the nucleosome is the repeating unit. The
mechanism by which RNA polymerase II (RNAPII) transcribes the nucleosomal DNA …

Nucleosomes, the basic units of chromatin, package and regulate expression of eukaryotic
genomes. Although the structure of the intact nucleosome is well characterized, little is …

Nucleosomes are disrupted during transcription and other active processes, but the
structural intermediates during nucleosome disruption in vivo are unknown. To identify …

Facilitates chromatin transcription (FACT) plays essential roles in chromatin remodeling
during DNA transcription, replication, and repair. Our structural and biochemical studies of …

The genomes of all organisms throughout the tree of life are compacted and organized in
chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which …

Gene regulation in eukaryotes requires the controlled access of sequence-specific
transcription factors (TFs) to their sites in a chromatin landscape dominated by …