Interest in neurofilaments has risen sharply in recent years with recognition of their potential
as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context …

Heat shock 70 kDa proteins (HSP70s) are ubiquitous molecular chaperones that function in
a myriad of biological processes, modulating polypeptide folding, degradation and …

INTRODUCTION Coral reefs worldwide are suffering losses at an alarming rate as a result of
anthropogenic climate change. Increased seawater temperatures, even only slightly above …

Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering,
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …

Mitochondria are crucial cellular organelles. Under extracellular stimulations, mitochondria
undergo constant fusion and fission dynamics to meet different cellular demands …

Maintenance of protein homeostasis is vitally important in post-mitotic cells, particularly
neurons. Neurodegenerative diseases such as polyglutamine expansion disorders—like …

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a childhood-onset
neurological disease resulting from mutations in the SACS gene encoding sacsin, a 4,579 …

Background Ataxia is a sign of different disorders involving any level of the nervous system
and consisting of impaired coordination of movement and balance. It is mainly caused by …

Autosomal recessive spastic ataxia of Charlevoix-Saguenay is a fatal brain disorder
featuring cerebellar neurodegeneration leading to spasticity and ataxia. This disease is …

There are numerous human diseases that are associated with protein misfolding and the
formation of toxic protein aggregates. Activating the heat shock response (HSR)–and thus …