Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Microglia, being the resident immune cells of the central nervous system, play an important
role in maintaining tissue homeostasis and contributes towards brain development under …

Alzheimer's disease (AD) is a neurodegenerative disorder molecularly characterized by the
formation of amyloid β (Aβ) plaques and type 2 microtubule-associated protein (Tau) …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Microglia are brain-resident myeloid cells that mediate key functions to support the CNS.
Microglia express a wide range of receptors that act as molecular sensors, which recognize …

Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …

Amyloid plaques, mainly composed of abnormally aggregated amyloid β-protein (Aβ) in the
brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau …

Toll-like receptors (TLRs) are discovered as crucial pattern recognition receptors (PRRs)
involved in the recognition of pathogen-associated molecular patterns (PAMPs). Later …

Haplodeficiency of the microglia gene TREM2 increases risk for late-onset Alzheimer's
disease (AD) but the mechanisms remain uncertain. To investigate this, we used high …