The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

The invention provides compounds of the formula:(I) wherein R1 is aryl, heteroaryl,
cycloalkyl or alkyl; R2 is H, alkyl, nitro, CO2R7, CONR5R6 or halo; R3 and R4 are H …

Characterization of the key cellular targets contributing to sustained microglial activation in
neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of …

The Kv1. 3 potassium channel is expressed abundantly on activated T cells and mediates
the cellular immune response. This role has made the channel a target for therapeutic …

Recently published work and emerging research efforts have suggested that the olfactory
system is intimately linked with the endocrine systems that regulate or modify energy …

Insulin is now well-established as playing multiple roles within the brain, and specifically as
regulating hippocampal cognitive processes and metabolism. Impairments to insulin …

Human immunodeficiency virus type 1 (HIV) infection presently affects more that 40 million
people worldwide, and is associated with central nervous system (CNS) disruption in at least …

Electrophysiological and pharmacological studies coupled with molecular identification
have revealed a unique network of ion channels—Kv1. 3, KCa3. 1, CRAC (Orai1+ Stim1) …

The role of insulin pathways in olfaction is of significant interest with the widespread
pathology of diabetes mellitus and its associated metabolic and neuronal comorbidities. The …

The insulin-regulated glucose transporter-4 (GluT4) is critical for insulin-and contractile-
mediated glucose uptake in skeletal muscle. GluT4 is also expressed in some hippocampal …