Role of JAK/STAT3 signaling in the regulation of metastasis, the transition of cancer stem cells, and chemoresistance of cancer by epithelial–mesenchymal transition
W Jin - Cells, 2020 - mdpi.com
The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …
Beneficial and detrimental aspects of miRNAs as chief players in breast cancer: a comprehensive review
Breast cancer (BC) is the most common cancer in women and poses a serious threat to their
health. Despite familiarity with factors affecting its etiology, initiation, progression, treatment …
health. Despite familiarity with factors affecting its etiology, initiation, progression, treatment …
A network-biology perspective of microRNA function and dysfunction in cancer
MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …
and consequently have roles in many pathologies, including cancer. These small non …
Clustered miRNAs and their role in biological functions and diseases
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
Systems and synthetic microRNA biology: from biogenesis to disease pathogenesis
H Matsuyama, HI Suzuki - International journal of molecular sciences, 2019 - mdpi.com
MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …
Covert actions of growth hormone: fibrosis, cardiovascular diseases and cancer
Since its discovery nearly a century ago, over 100,000 studies of growth hormone (GH) have
investigated its structure, how it interacts with the GH receptor and its multiple actions. These …
investigated its structure, how it interacts with the GH receptor and its multiple actions. These …
The emerging role of miRNA clusters in breast cancer progression
Micro RNAs (miRNAs) are small non-coding RNAs that are essential for regulation of gene
expression of the target genes. Large number of miRNAs are organized into defined units …
expression of the target genes. Large number of miRNAs are organized into defined units …
MicroRNAs' role in the environment-related non-communicable diseases and link to multidrug resistance, regulation, or alteration
The discovery of microRNAs (miRNAs) 20 years ago has advocated a new era of “small
molecular genetics.” About 2000 miRNAs are present that regulate one third of the genome …
molecular genetics.” About 2000 miRNAs are present that regulate one third of the genome …
miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer
Y Hong, H Liang, Y Wang, W Zhang, Y Zhou, S Chen… - Scientific reports, 2016 - nature.com
Abstract microRNAs (miRNAs) have emerged as major regulators of the initiation and
progression of human cancers, including breast cancer. The aim of this study is to determine …
progression of human cancers, including breast cancer. The aim of this study is to determine …
Emerging role of microRNAs in mTOR signaling
Y Zhang, B Huang, HY Wang, A Chang… - Cellular and Molecular …, 2017 - Springer
Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase that plays a
critical role in the control of cellular growth and metabolism. Hyperactivation of mTOR …
critical role in the control of cellular growth and metabolism. Hyperactivation of mTOR …