The clinical description that defines acute lung injury (ALI) has been around for more than
50 years. The clinical picture has carried many different definitions, but what was known as …

Ventilation is inherently a dynamic process. The present-day clinical practice of
concentrating on the static inflation characteristics of the individual tidal cycle (plateau …

The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the
European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to …

Several factors have been recognized as possible triggers of ventilator-induced lung injury
(VILI). The first is pressure (thus the 'barotrauma'), then the volume (hence the 'volutrauma') …

Purpose Experimental animal models of acute respiratory distress syndrome (ARDS) have
shown that the updated airway pressure release ventilation (APRV) methodologies may …

Background In ARDS patients, mechanical ventilation should minimize ventilator-induced
lung injury. The mechanical power which is the energy per unit time released to the …

Fifty years ago, Ashbaugh and colleagues defined for the first time the acute respiratory
distress syndrome (ARDS), one among the most challenging clinical condition of the critical …

Purpose This study aimed at investigating the mechanisms underlying the oxygenation
response to proning and recruitment maneuvers in coronavirus disease 2019 (COVID-19) …

Background Mechanical power is a summary variable including all the components which
can possibly cause VILI (pressures, volume, flow, respiratory rate). Since the complexity of …

In patients with the acute respiratory distress syndrome (ARDS), lung imaging is a
fundamental tool in the study of the morphological and mechanistic features of the lungs …