Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …

Noise permeates biology on all levels, from the most basic molecular, sub-cellular
processes to the dynamics of tissues, organs, organisms and populations. The functional …

Persisters are transiently antibiotic-tolerant cells that complicate the treatment of bacterial
infections. Both theory and experiments have suggested that persisters facilitate genetic …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

All bacterial populations harbor a small fraction of transiently antibiotic-tolerant cells called
persisters. These phenotypic variants compromise successful antibiotic treatment because …

Highlights•Genes and genetic circuits exhibit growth-rate dependence.•Growth rate
dependence reflects coupling of gene expression and physiological state of the cell.•Several …

Recent laboratory evolution studies have shown that upon repetitive antibiotic treatments,
bacterial populations will adapt and eventually became tolerant and resistant to the drug …

The evolution of antibiotic resistance is a major threat to society and has been predicted to
lead to 10 million casualties annually by 2050 1. Further aggravating the problem, multidrug …

Bacteria have at their disposal a battery of strategies to withstand antibiotic stress. Among
these, resistance is a well-known mechanism, yet bacteria can also survive antibiotic attack …

Strict anaerobic gut microbes have been suggested as 'next‐generation probiotics' for
treating several intestinal disorders. The development of preservation techniques is of major …