Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Preclinical and clinical studies implicate endocannabinoids (eCBs) in fear extinction, but the
underlying neural circuit basis of these actions is unclear. Here, we employed in vivo …

The differential vulnerability of dopaminergic neurons of the substantia nigra pars compacta
(SNc) is a critical and unresolved question in Parkinson´ s disease. Studies in mice show …

Genome-wide association studies (GWASs) have identified numerous susceptibility loci for
Parkinson's disease (PD), but its genetic architecture remains underexplored in populations …

The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …

As the ability to capture single-cell expression profiles has grown in recent years,
neuroscientists studying a wide gamut of brain regions have discovered remarkable …

GBA1 variants are important risk factors for Parkinson's disease (PD). Most studies
assessing GBA1-related PD risk have been performed in European-derived populations …

Abstract 2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE47) is a foodborne environmental risk
factor for depression, but the pathogenic mechanism has yet to be fully characterized. In this …

Objective To assess the prevalence, evolution, clinical characteristics, correlates and
predictors of fatigue as well as to investigate the influence of comorbid fatigue on the …

Parkinson's disease (PD) is featured by movement impairments, including tremors,
bradykinesia, muscle stiffness, and imbalance. PD is also associated with many non-motor …