Cancer-associated pathways and biomarkers of venous thrombosis

Y Hisada, N Mackman - Blood, The Journal of the American …, 2017 - ashpublications.org
Cancer patients have an increased risk of venous thromboembolism (VTE). In this review,
we summarize common and cancer type–specific pathways of VTE in cancer patients …

Platelets at the interface of thrombosis, inflammation, and cancer

AT Franco, A Corken, J Ware - Blood, The Journal of the …, 2015 - ashpublications.org
Although once primarily recognized for its roles in hemostasis and thrombosis, the platelet
has been increasingly recognized as a multipurpose cell. Indeed, circulating platelets have …

New concepts and mechanisms of platelet activation signaling

B Estevez, X Du - Physiology, 2017 - journals.physiology.org
Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

New fundamentals in hemostasis

HH Versteeg, JWM Heemskerk, M Levi… - Physiological …, 2013 - journals.physiology.org
Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

The molecular interaction of collagen with cell receptors for biological function

J Elango, C Hou, B Bao, S Wang… - Polymers, 2022 - mdpi.com
Collagen, an extracellular protein, covers the entire human body and has several important
biological functions in normal physiology. Recently, collagen from non-human sources has …

Understanding infection-induced thrombosis: lessons learned from animal models

N Beristain-Covarrubias, M Perez-Toledo… - Frontiers in …, 2019 - frontiersin.org
Thrombosis is a common consequence of infection that is associated with poor patient
outcome. Nevertheless, the mechanisms by which infection-associated thrombosis is …

[HTML][HTML] Ibrutinib‐associated bleeding: pathogenesis, management and risk reduction strategies

JJ Shatzel, SR Olson, DL Tao, OJT McCarty… - Journal of thrombosis …, 2017 - Elsevier
Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (Btk) that has proven to be an
effective therapeutic agent for multiple B‐cell‐mediated lymphoproliferative disorders …

Thrombocytopenia in dengue: interrelationship between virus and the imbalance between coagulation and fibrinolysis and inflammatory mediators

EL Azeredo, RQ Monteiro… - Mediators of …, 2015 - Wiley Online Library
Dengue is an infectious disease caused by dengue virus (DENV). In general, dengue is a
self‐limiting acute febrile illness followed by a phase of critical defervescence, in which …

Platelets at work in primary hemostasis

K Broos, HB Feys, SF De Meyer, K Vanhoorelbeke… - Blood reviews, 2011 - Elsevier
When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

[HTML][HTML] Regulation of platelet activation and thrombus formation by reactive oxygen species

J Qiao, JF Arthur, EE Gardiner, RK Andrews, L Zeng… - Redox biology, 2018 - Elsevier
Reactive oxygen species (ROS) are generated within activated platelets and play an
important role in regulating platelet responses to collagen and collagen-mediated thrombus …