Harnessing big 'omics' data and AI for drug discovery in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common form of primary adult liver cancer. After
nearly a decade with sorafenib as the only approved treatment, multiple new agents have …
nearly a decade with sorafenib as the only approved treatment, multiple new agents have …
Genomics and signaling pathways in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of death among cirrhotic patients and
has become a major health problem in developed countries. There is an elemental …
has become a major health problem in developed countries. There is an elemental …
Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
L Gramantieri, M Ferracin, F Fornari, A Veronese… - Cancer research, 2007 - AACR
We investigated the role of microRNAs (miRNAs) in the pathogenesis of human
hepatocellular carcinoma (HCC). A genome-wide miRNA microarray was used to identify …
hepatocellular carcinoma (HCC). A genome-wide miRNA microarray was used to identify …
MicroRNAs: control and loss of control in human physiology and disease
M Li, C Marin-Muller, U Bharadwaj, KH Chow… - World journal of …, 2009 - Springer
Abstract Analysis of the human genome indicates that a large fraction of the genome
sequences are RNAs that do not encode any proteins, also known as non-coding RNAs …
sequences are RNAs that do not encode any proteins, also known as non-coding RNAs …
Extracellular matrix and liver disease
E Arriazu, M Ruiz de Galarreta, FJ Cubero… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: The extracellular matrix (ECM) is a dynamic microenvironment that undergoes
continuous remodeling, particularly during injury and wound healing. Chronic liver injury of …
continuous remodeling, particularly during injury and wound healing. Chronic liver injury of …
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma
We describe a system that permits conditional mobilization of a Sleeping Beauty (SB)
transposase allele by Cre recombinase to induce cancer specifically in a tissue of interest …
transposase allele by Cre recombinase to induce cancer specifically in a tissue of interest …
[HTML][HTML] LncRNA CRNDE promotes hepatic carcinoma cell proliferation, migration and invasion by suppressing miR-384
Z Chen, C Yu, L Zhan, Y Pan, L Chen… - American journal of …, 2016 - ncbi.nlm.nih.gov
Studies have found that colorectal neoplasia differentially expressed (CRNDE) is related to
cancer development. Herein, we found that the expression of CRNDE was increased in …
cancer development. Herein, we found that the expression of CRNDE was increased in …
Radiogenomic analysis to identify imaging phenotypes associated with drug response gene expression programs in hepatocellular carcinoma
PURPOSE: To determine whether conventional contrast-enhanced computed tomography
(CT) could be used to identify imaging phenotypes associated with a doxorubicin drug …
(CT) could be used to identify imaging phenotypes associated with a doxorubicin drug …
Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein
S Sato, M Fukasawa, Y Yamakawa… - Journal of …, 2006 - academic.oup.com
Hepatitis C virus (HCV) core protein has been suggested to play crucial roles in the
pathogeneses of liver steatosis and hepatocellular carcinomas due to HCV infection …
pathogeneses of liver steatosis and hepatocellular carcinomas due to HCV infection …
[PDF][PDF] MicroRNAs‐372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B
H Guo, H Liu, K Mitchelson, H Rao, M Luo, L Xie… - …, 2011 - Wiley Online Library
MicroRNAs (miRNAs) play important roles in the posttranscriptional regulation of gene
expression. Recent evidence has indicated the pathological relevance of miRNA …
expression. Recent evidence has indicated the pathological relevance of miRNA …