Cells on chips

J El-Ali, PK Sorger, KF Jensen - Nature, 2006 - nature.com
Microsystems create new opportunities for the spatial and temporal control of cell growth
and stimuli by combining surfaces that mimic complex biochemistries and geometries of the …

Miniature bioreactors: current practices and future opportunities

JI Betts, F Baganz - Microbial cell factories, 2006 - Springer
This review focuses on the emerging field of miniature bioreactors (MBRs), and examines
the way in which they are used to speed up many areas of bioprocessing. MBRs aim to …

Advances in microfluidic devices made from thermoplastics used in cell biology and analyses

E Gencturk, S Mutlu, KO Ulgen - Biomicrofluidics, 2017 - pubs.aip.org
Silicon and glass were the main fabrication materials of microfluidic devices, however,
plastics are on the rise in the past few years. Thermoplastic materials have recently been …

A review of advanced small‐scale parallel bioreactor technology for accelerated process development: Current state and future need

R Bareither, D Pollard - Biotechnology progress, 2011 - Wiley Online Library
The pharmaceutical and biotech industries face continued pressure to reduce development
costs and accelerate process development. This challenge occurs alongside the need for …

Optical oxygen sensors for applications in microfluidic cell culture

SM Grist, L Chrostowski, KC Cheung - Sensors, 2010 - mdpi.com
The presence and concentration of oxygen in biological systems has a large impact on the
behavior and viability of many types of cells, including the differentiation of stem cells or the …

Lab-on-a-chip: a component view

YC Lim, AZ Kouzani, W Duan - Microsystem Technologies, 2010 - Springer
Miniaturization is being increasingly applied to biological and chemical analysis processes.
Lab-on-a-chip systems are direct creation of the advancement in the miniaturization of these …

Quantitative measurement and control of oxygen levels in microfluidic poly (dimethylsiloxane) bioreactors during cell culture

G Mehta, K Mehta, D Sud, JW Song… - Biomedical …, 2007 - Springer
Microfluidic bioreactors fabricated from highly gas-permeable poly (dimethylsiloxane)(PDMS
) materials have been observed, somewhat unexpectedly, to give rise to heterogeneous …

Development of novel bioreactor control systems based on smart sensors and actuators

B Wang, Z Wang, T Chen, X Zhao - Frontiers in bioengineering and …, 2020 - frontiersin.org
Bioreactors of various forms have been widely used in environmental protection, healthcare,
industrial biotechnology, and space exploration. Robust demand in the field stimulated the …

Application of microbioreactors in fermentation process development: a review

D Schäpper, MNHZ Alam, N Szita… - Analytical and …, 2009 - Springer
Biotechnology process development involves strain testing and improvement steps aimed at
increasing yields and productivity. This necessitates the high-throughput screening of many …

Recent advances in microfluidic devices for bacteria and fungus research

W Zhou, J Le, Y Chen, Y Cai, Z Hong, Y Chai - TrAC Trends in Analytical …, 2019 - Elsevier
Microorganisms are not only common pathogens in clinical practice, but also an important
participant in the maintenance of ecological balance, which plays a vital role in food …