[HTML][HTML] Discovery and development of safe-in-man broad-spectrum antiviral agents

PI Andersen, A Ianevski, H Lysvand… - International Journal of …, 2020 - Elsevier
Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-
specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases …

H3N2 influenza viruses in humans: Viral mechanisms, evolution, and evaluation

JD Allen, TM Ross - Human vaccines & immunotherapeutics, 2018 - Taylor & Francis
Annual seasonal influenza vaccines are composed of two influenza A strains representing
the H1N1 and H3N2 subtypes, and two influenza B strains representing the Victoria and …

[PDF][PDF] Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury

Y Liu, C Zhang, F Huang, Y Yang, F Wang… - National Science …, 2020 - academic.oup.com
A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel
coronavirus (2019-nCoV or SARS-CoV-2 or HCoV-19). We previously reported the clinical …

Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3

RA Campbell, H Schwertz, ED Hottz… - Blood, The Journal …, 2019 - ashpublications.org
Evolving evidence indicates that platelets and megakaryocytes (MKs) have unexpected
activities in inflammation and infection; whether viral infections upregulate biologically …

Benzothiazoles as potential antiviral agents

YI Asiri, A Alsayari, AB Muhsinah… - Journal of Pharmacy …, 2020 - academic.oup.com
Objectives The recent viral pandemic poses a unique challenge for healthcare providers.
Despite the remarkable progress, the number of novel antiviral agents in the pipeline is …

Consequences of viral infection and cytokine production during pregnancy on brain development in offspring

D Elgueta, P Murgas, E Riquelme, G Yang… - Frontiers in …, 2022 - frontiersin.org
Infections during pregnancy can seriously damage fetal neurodevelopment by aberrantly
activating the maternal immune system, directly impacting fetal neural cells. Increasing …

Bioactive compounds from mangrove endophytic fungus and their uses for microorganism control

RD Cadamuro, IMA da Silveira Bastos, IT Silva… - Journal of fungi, 2021 - mdpi.com
Mangroves are ecosystems with unique characteristics due to the high salinity and amount
of organic matter that house a rich biodiversity. Fungi have aroused much interest as they …

Respiratory Barrier as a Safeguard and Regulator of Defense Against Influenza A Virus and Streptococcus pneumoniae

KS LeMessurier, M Tiwary, NP Morin… - Frontiers in …, 2020 - frontiersin.org
The primary function of the respiratory system of gas exchange renders it vulnerable to
environmental pathogens that circulate in the air. Physical and cellular barriers of the …

Treating influenza infection, from now and into the future

S Davidson - Frontiers in immunology, 2018 - frontiersin.org
Influenza viruses (IVs) are a continual threat to global health. The high mutation rate of the IV
genome makes this virus incredibly successful, genetic drift allows for annual epidemics …

Synergistic interferon-alpha-based combinations for treatment of SARS-CoV-2 and other viral infections

A Ianevski, R Yao, E Zusinaite, LS Lello, S Wang, E Jo… - Viruses, 2021 - mdpi.com
Background: There is an urgent need for new antivirals with powerful therapeutic potential
and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons …