Recent molecular studies have expanded the biological contexts in which topoisomerase II
(TOP2) has crucial functions, including DNA replication, transcription and chromosome …

DNA topoisomerases (topos) are essential enzymes that regulate the topological state of
DNA during cellular processes such as replication, transcription, recombination, and …

A series of novel 7-substituted 10, 11-methylenedioxy-camptothecin (FL118) derivatives
were designed, synthesized, and biologically evaluated. All the FL118 analogues showed …

Irinotecan and topotecan are the only camptothecin analogues approved by the FDA for
cancer treatment. However, inherent and/or acquired irinotecan and topotecan resistance is …

Breast cancer resistance protein (BCRP/ABCG2) was discovered in multidrug resistant
breast cancer cells having an ATP-dependent transport-based resistance phenotype. This …

The topoisomerase family is a group of enzymes that orchestrate DNA topology and is
required to uniform genetic makeup during replication, recombination, and transcription …

10, 11-Methylenedioxy-camptothecin (FL118) is a novel camptothecin analogue that
possesses exceptional antitumor efficacy in human tumor xenograft models. The aim of the …

Two ruthenium (II) polypyridyl complexes,[Ru (dppz) 2 dppz-11-CO 2 Me](ClO 4) 2 (Ru1)
and [Ru (dppz) 3](ClO 4) 2 (Ru2), have been synthesized and characterized. The spectral …

Background AZD8055 is a small molecule ATP‐competitive inhibitor of the serine/threonine
kinase mTOR that regulates cap‐dependent translation through the mTORC1 complex and …

Two ruthenium (II) polypyridyl complexes containing 1, 8-naphthalimide group as DNA
binders, photonucleases, and inhibitors of topoisomerases I and IIα are evaluated. The …