Patient-reported outcomes (PROs) provide important insights into patients' own perspectives
about their health and medical condition, and there is evidence that their use can lead to …

There is notable heterogeneity in how clinical and phenotypic data are measured by mental
health researchers. There is a proliferation of self-report measures (eg, over 280 for …

Abstract Background The International Consortium for Health Outcomes Measurement
(ICHOM) develops condition-specific Standard Sets of outcomes to be measured in clinical …

Background Healthcare systems around the world experience increasing pressure to control
future growth of healthcare expenditures. Among other initiatives, quality and value-based …

Background Self-monitoring of blood pressure is a key strategy in managing hypertension
but may be challenging and burdensome for patients. The aim of the study was to describe …

Background Drug repurposing aims to detect the new therapeutic benefits of the existing
drugs and reduce the spent time and cost of the drug development projects. The synthetic …

Background Life course epidemiology is a powerful framework to unravel the role of
socioeconomic position (SEP) disparities in hypertension (HTN). This study investigated …

Objectives A core outcome set (COS) describes a minimum set of outcomes to be reported
by all clinical trials of one healthcare condition. Delphi surveys are frequently used to …

Hypertension is a major contributor to global morbidity and mortality. In South Africa, the
government has employed a whole systems approach to address the growing burden of non …

Background. Sympathetic activation leads to elevated blood pressure. Neuronal nitric oxide
synthase (nNOS) inhibits sympathetic nervous system activity, thereby decreasing blood …