Progress in mass spectrometry lipidomics has led to a rapid proliferation of studies across
biology and biomedicine. These generate extremely large raw datasets requiring …

Lipids are vital biological molecules and play multiple roles in cellular function of
mammalian organisms such as cellular membrane anchoring, signal transduction, material …

Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to
hepatic steatosis. However, NAFLD's global impact on the liver lipidome is poorly …

Expanding metabolome coverage to include complex lipids and polar metabolites is
essential in the generation of well-founded hypotheses in biological assays. Traditionally …

Shotgun lipidomics has recently gained popularity for lipid analysis. Conventionally, shotgun
analysis of glycerophospholipids via direct electrospray ionization tandem mass …

Despite the tremendous success, pitfalls have been observed in every step of a clinical
metabolomics workflow, which impedes the internal validity of the study. Furthermore, the …

Over 1500 different lipids have been reported in human plasma at the sum composition
level. Yet the number of unique lipids present is surely higher, once isomeric contributions …

Lipids play a key role in many biological processes, and their accurate measurement is
critical to unraveling the biology of diseases and human health. A high throughput HILIC …

This review summarizes available mass spectrometry (MS) based approaches for the
quantitative analysis of lipids in biological samples in the cancer research, which is termed …

Nonpolar triglycerides (TGs) are rarely detected in mass spectrometry imaging (MSI)
experiments unless they are abundant in the sample. Herein, we use nanospray desorption …