Leishmaniasis is a vector-borne neglected tropical disease that affects more than 700,000
people annually. Leishmania parasites cause the disease, and different species trigger a …

Current understanding of key cellular pathways, which are activated by the interaction
between T. cruzi and host immunity, is crucial for controlling T. cruzi infection and also for …

Chagas disease is a complex zoonosis. Clinically, it presents in two distinct phases, acute
and chronic. The ability of patients to respond to Trypanosoma cruzi infection depends on …

Macrophages play important roles in the innate and acquired immune responses against
Leishmania parasites. Depending on the subset and activation status, macrophages may …

During the onset of Trypanosoma cruzi infection, an effective immune response is necessary
to control parasite replication and ensure host survival. Macrophages have a central role in …

Macrophages can reprogram their metabolism in response to the surrounding stimuli, which
affects their capacity to kill intracellular pathogens. We have investigated the metabolic and …

The causative agent of Chagas' disease, Trypanosoma cruzi, affects approximately 10
million people living mainly in Latin America, with macrophages being one of the first …

Chagas disease is a neglected tropical disease with only two drugs available for treatment
and the plant Cecropia pachystachya has several compounds with antimicrobial and anti …

The majority of lung diseases occur with a sex bias in terms of prevalence and/or severity.
Previous studies demonstrated that, compared with males, female mice develop greater …

Chagas disease, caused by Trypanosoma cruzi, stands as the primary cause of dilated
cardiomyopathy in the Americas. Macrophages play a crucial role in the heart's response to …