Community-acquired bacterial coinfections and COVID-19

MJ Patton, A Gaggar, M Might… - Physiological …, 2024 - journals.physiology.org
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the 29
causative pathogen of Coronavirus disease 2019 (COVID-19), has resulted in over 650 30 …

Saline nasal irrigation and gargling in COVID-19: a multidisciplinary review of effects on viral load, mucosal dynamics, and patient outcomes

S Huijghebaert, S Parviz, D Rabago, A Baxter… - Frontiers in Public …, 2023 - frontiersin.org
With unrelenting SARS-CoV-2 variants, additional COVID-19 mitigation strategies are
needed. Oral and nasal saline irrigation (SI) is a traditional approach for respiratory …

Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration

Y Mikami, BR Grubb, TD Rogers, H Dang… - Science translational …, 2023 - science.org
Unlike solid organs, human airway epithelia derive their oxygen from inspired air rather than
the vasculature. Many pulmonary diseases are associated with intraluminal airway …

Human airway basal cells undergo reversible squamous differentiation and reshape innate immunity

Y Zhang, KE Black, TKN Phung… - American journal of …, 2023 - atsjournals.org
Histological and lineage immunofluorescence examination revealed that healthy conducting
airways of humans and animals harbor sporadic poorly differentiated epithelial patches …

[HTML][HTML] Lung remodeling regions in long-term coronavirus disease 2019 feature basal epithelial cell reprogramming

K Wu, Y Zhang, SR Austin, H Yin-Declue… - The American Journal of …, 2023 - Elsevier
Respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), can trigger chronic lung disease that persists and even progresses after expected …

Mitogen-activated protein kinase-guided drug discovery for post-viral and related types of lung disease

MJ Holtzman, Y Zhang, K Wu… - European Respiratory …, 2024 - Eur Respiratory Soc
Respiratory viral infections are a major public health problem, with much of their morbidity
and mortality due to post-viral lung diseases that progress and persist after the active …

Interstitial lung abnormalities after hospitalization for COVID‐19 in patients with cancer: A prospective cohort study

S Noh, C Bertini, I Mira‐Avendano, M Kaous… - Cancer …, 2023 - Wiley Online Library
Abstract Introduction Survivors of SARS‐CoV‐2 pneumonia often develop persistent
respiratory symptom and interstitial lung abnormalities (ILAs) after infection. Risk factors for …

Mucociliary clearance augmenting drugs block SARS-CoV-2 replication in human airway epithelial cells

J Campos-Gomez, C Fernandez Petty… - … of Physiology-Lung …, 2023 - journals.physiology.org
The coronavirus disease (COVID-19) pandemic, caused by SARS-CoV-2 coronavirus, is
devastatingly impacting human health. A prominent component of COVID-19 is the infection …

[HTML][HTML] Deep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury

Y Mao, Y Chen, Y Li, L Ma, X Wang, Q Wang, A He… - Cell Reports, 2024 - cell.com
As a primary target of severe acute respiratory syndrome coronavirus 2, lung exhibits
heterogeneous histopathological changes following infection. However, comprehensive …

Targeting epidermal growth factor receptor signalling pathway: A promising therapeutic option for COVID‐19

A Razzaq, C Disoma, Y Zhou, S Tao… - Reviews in Medical …, 2024 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is continuously
producing new variants, necessitating effective therapeutics. Patients are not only …