Photocatalytic late-stage C–H functionalization
The emergence of modern photocatalysis, characterized by mildness and selectivity, has
significantly spurred innovative late-stage C–H functionalization approaches that make use …
significantly spurred innovative late-stage C–H functionalization approaches that make use …
The mechanism of visible light-induced C–C cross-coupling by C sp3–H bond activation
Csp3–C cross-coupling by activating Csp3–H bonds is a dream reaction for the chemical
community, and visible light-induced transition metal-catalysis under mild reaction …
community, and visible light-induced transition metal-catalysis under mild reaction …
Metallaphotoredox-enabled aminocarboxylation of alkenes with CO2
JP Yue, JC Xu, HT Luo, XW Chen, HX Song, Y Deng… - Nature Catalysis, 2023 - nature.com
The conversion of CO2 to valuable chemicals is highly desirable for sustainable
development. Among the various methods available, the difunctionalizing carboxylation of …
development. Among the various methods available, the difunctionalizing carboxylation of …
Regioselective aliphatic C–H functionalization using frustrated radical pairs
Abstract Frustrated Lewis pairs (FLPs) are well documented for the activation of small
molecules such as dihydrogen and carbon dioxide,,–. Although canonical FLP chemistry is …
molecules such as dihydrogen and carbon dioxide,,–. Although canonical FLP chemistry is …
Electrophotocatalytic decoupled radical relay enables highly efficient and enantioselective benzylic C–H functionalization
W Fan, X Zhao, Y Deng, P Chen… - Journal of the American …, 2022 - ACS Publications
Asymmetric sp3 C–H functionalization has been demonstrated to substantially expedite
target molecule synthesis, spanning from feedstocks upgradation to late-stage modification …
target molecule synthesis, spanning from feedstocks upgradation to late-stage modification …
Photoelectrochemical oxidative C(sp3)−H borylation of unactivated hydrocarbons
PF Zhong, JL Tu, Y Zhao, N Zhong, C Yang… - Nature …, 2023 - nature.com
Organoboron compounds are of high significance in organic synthesis due to the unique
versatility of boryl substituents to access further modifications. The high demand for the …
versatility of boryl substituents to access further modifications. The high demand for the …
Site- and enantioselective cross-coupling of saturated N-heterocycles with carboxylic acids by cooperative Ni/photoredox catalysis
X Shu, D Zhong, Q Huang, L Huan, H Huo - Nature Communications, 2023 - nature.com
Site-and enantioselective cross-coupling of saturated N-heterocycles and carboxylic acids—
two of the most abundant and versatile functionalities—to form pharmaceutically relevant α …
two of the most abundant and versatile functionalities—to form pharmaceutically relevant α …
Benzylic C–H esterification with limiting C–H substrate enabled by photochemical redox buffering of the Cu catalyst
Copper-catalyzed radical-relay reactions provide a versatile strategy for selective C–H
functionalization; however, reactions with peroxide-based oxidants often require excess C …
functionalization; however, reactions with peroxide-based oxidants often require excess C …
Enantioselective alkylation of α-amino C(sp3)−H bonds via photoredox and nickel catalysis
J Li, B Cheng, X Shu, Z Xu, C Li, H Huo - Nature Catalysis, 2024 - nature.com
The catalytic enantioselective construction of C (sp 3)− C (sp 3) bonds remains a substantial
challenge in organic synthesis. One particularly promising approach is the use of transition …
challenge in organic synthesis. One particularly promising approach is the use of transition …
Polar Heterobenzylic C(sp3)–H Chlorination Pathway Enabling Efficient Diversification of Aromatic Nitrogen Heterocycles
Site-selective radical reactions of benzylic C–H bonds are now highly effective methods for
C (sp3–H) functionalization and cross-coupling. The existing methods, however, are often …
C (sp3–H) functionalization and cross-coupling. The existing methods, however, are often …