Melanin-concentrating hormone (MCH) is a small cyclic peptide expressed in all mammals,
mainly in the hypothalamus. MCH acts as a robust integrator of several physiological …

Energy balance is maintained via a homeostatic system involving both the brain and the
periphery. A key component of this system is the hypothalamus. Over the past two decades …

The physiological signaling mechanisms that link normal variations in body energy status to
the activity of arousal-and metabolism-regulating brain centers are not well understood. The …

Current therapeutic strategies are proving inadequate to deal with growing obesity rates
because of the inherent resistance of the human body to weight loss. The activation of …

Survival depends on an organism's ability to sense nutrient status and accordingly regulate
intake and energy expenditure behaviors. Uncoupling of energy sensing and behavior …

The melanin-concentrating hormone (MCH) is an important peptide implicated in the control
of motivated behaviors. History, however, made this peptide first known for its participation in …

Objective: To determine whether the anorexigenic peptide, nesfatin-1 affects energy
expenditure, and to follow the time course of its effects. Design: Food intake duration, core …

Dysfunction of specific hypothalamic neurons is regarded as an important mechanism
predisposing to the development of obesity. Recent studies have revealed that the …

The hypocretin (Hcrt) system has been implicated in a wide range of physiological functions
from sleep-wake regulation to cardiovascular, behavioral, metabolic, and thermoregulagtory …

Extensive studies were performed to decipher the mechanisms regulating feeding due to the
worldwide obesity pandemy and its complications. The data obtained might be adapted to …