The efficient study of human disease requires the proper tools, one of the most crucial of
which is an accurate animal model that faithfully recapitulates the human condition. The …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive, neurodegenerative disease
characterized by loss of upper motor neurons (UMN) and lower motor neurons (LMN) …

Background Potential biomarkers to aid diagnosis and therapy need to be identified for
Amyotrophic Lateral Sclerosis, a progressive motor neuronal degenerative disorder. The …

To test the hypothesis that the cerebrospinal fluid (CSF) could provide a spreading route for
pathogenesis of amyotrophic lateral sclerosis (ALS), we have examined the effects of …

Despite the considerable progress made towards understanding ALS pathophysiology,
several key features of ALS remain unexplained, from its aetiology to its epidemiological …

Background Non-cell autonomous toxicity is one of the potential mechanisms implicated in
the etiopathogenesis of amyotrophic lateral sclerosis (ALS). However, the exact role of glial …

Background Cerebrospinal fluid from amyotrophic lateral sclerosis patients (ALS-CSF)
induces neurodegenerative changes in motor neurons and gliosis in sporadic ALS models …

Background Microglial cell-associated neuroinflammation is considered as a potential
contributor to the pathophysiology of sporadic amyotrophic lateral sclerosis. However, the …

The neurotoxic effects of cerebrospinal fluid (CSF) from patients suffering amyotrophic
lateral sclerosis (ALS), have been reported by various authors. However, variable results …

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by motor
neuron degeneration. Approximately 90% of cases occur sporadically with no known cause …