Kidney metabolism and acid–base control: back to the basics
PH Imenez Silva, N Mohebbi - Pflügers Archiv-European Journal of …, 2022 - Springer
Kidneys are central in the regulation of multiple physiological functions, such as removal of
metabolic wastes and toxins, maintenance of electrolyte and fluid balance, and control of pH …
metabolic wastes and toxins, maintenance of electrolyte and fluid balance, and control of pH …
Cerebrospinal fluid pH regulation
HH Damkier, J Praetorius - Pflügers Archiv-European Journal of …, 2024 - Springer
The cerebrospinal fluid (CSF) fills the brain ventricles and the subarachnoid space
surrounding the brain and spinal cord. The fluid compartment of the brain ventricles …
surrounding the brain and spinal cord. The fluid compartment of the brain ventricles …
Antibodies toward Na+,HCO3–-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer
TV Axelsen, C Olesen, D Khan, A Mohammadi… - British Journal of …, 2024 - nature.com
Abstract Background Na+, HCO3–-cotransporter NBCn1/Slc4a7 accelerates murine breast
carcinogenesis. Lack of specific pharmacological tools previously restricted therapeutic …
carcinogenesis. Lack of specific pharmacological tools previously restricted therapeutic …
Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival
RA Sloth, TV Axelsen, MS Espejo, NJ Toft… - British Journal of …, 2022 - nature.com
Background While cellular metabolism and acidic waste handling accelerate during breast
carcinogenesis, temporal patterns of acid–base regulation and underlying molecular …
carcinogenesis, temporal patterns of acid–base regulation and underlying molecular …
State of knowledge on ammonia handling by the kidney
S Bourgeois, P Houillier - Pflügers Archiv-European Journal of Physiology, 2024 - Springer
The disposal of ammonia, the main proton buffer in the urine, is important for acid–base
homeostasis. Renal ammonia excretion is the predominant contributor to renal net acid …
homeostasis. Renal ammonia excretion is the predominant contributor to renal net acid …
The role of Na+-coupled bicarbonate transporters (NCBT) in health and disease
SR Holmberg, Y Sakamoto, A Kato… - Pflügers Archiv-European …, 2024 - Springer
Cellular and organism survival depends upon the regulation of pH, which is regulated by
highly specialized cell membrane transporters, the solute carriers (SLC)(For a …
highly specialized cell membrane transporters, the solute carriers (SLC)(For a …
[HTML][HTML] Na+/H+-exchange inhibition by cariporide is compensated via Na+, HCO3−-cotransport and has no net growth consequences for ErbB2-driven breast …
P Aaen, KB Kristensen, A Antony, SH Hansen… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Defense against intracellular acidification of breast cancer tissue depends on net acid
extrusion via Na+, HCO 3−-cotransporter NBCn1/Slc4a7 and Na+/H+-exchanger …
extrusion via Na+, HCO 3−-cotransporter NBCn1/Slc4a7 and Na+/H+-exchanger …
NH4Cl-induced metabolic acidosis increases the abundance of HCO3 − transporters in the choroid plexus of mice
LØ Johnsen, A Sigad, KA Friis, PM Berg… - Frontiers in …, 2024 - frontiersin.org
Regulation of cerebrospinal fluid (CSF) pH and brain pH are vital for all brain cells. The
acute regulation of CSF pH is dependent on the transport of HCO3− across the choroid …
acute regulation of CSF pH is dependent on the transport of HCO3− across the choroid …
Revisiting voltage-coupled H+ secretion in the collecting duct
N Ayasse, P Berg, MV Sørensen… - American Journal …, 2024 - journals.physiology.org
Experimental studies have shown that V-type ATPase-driven H+ secretion is dependent on
transepithelial voltage. On this basis, the “voltage hypothesis” of urinary acidification by the …
transepithelial voltage. On this basis, the “voltage hypothesis” of urinary acidification by the …
miRNA-23a modulates sodium-hydrogen exchanger 1 expression: studies in medullary thick ascending limb of salt-induced hypertensive rats
P Lombari, M Mallardo, O Petrazzuolo… - Nephrology Dialysis …, 2023 - academic.oup.com
Background The kidney is the main organ in the pathophysiology of essential hypertension.
Although most bicarbonate reabsorption occurs in the proximal tubule, the medullary thick …
Although most bicarbonate reabsorption occurs in the proximal tubule, the medullary thick …