Ribosome-targeting antibiotics: modes of action, mechanisms of resistance, and implications for drug design
J Lin, D Zhou, TA Steitz, YS Polikanov… - Annual review of …, 2018 - annualreviews.org
Genetic information is translated into proteins by the ribosome. Structural studies of the
ribosome and of its complexes with factors and inhibitors have provided invaluable …
ribosome and of its complexes with factors and inhibitors have provided invaluable …
Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights
Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from
Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have …
Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have …
Toward a global picture of bacterial secondary metabolism
MR Seyedsayamdost - Journal of Industrial Microbiology and …, 2019 - academic.oup.com
Bacterial metabolism is comprised of primary metabolites, the intracellular molecules of life
that enable growth and proliferation, and secondary metabolites, predominantly extracellular …
that enable growth and proliferation, and secondary metabolites, predominantly extracellular …
Acyl-homoserine lactone-dependent eavesdropping promotes competition in a laboratory co-culture model
Many Proteobacteria use acyl-homoserine lactone (AHL)-mediated quorum sensing to
activate the production of antibiotics at high cell density. Extracellular factors like antibiotics …
activate the production of antibiotics at high cell density. Extracellular factors like antibiotics …
Blast from the past: reassessing forgotten translation inhibitors, antibiotic selectivity, and resistance mechanisms to aid drug development
Protein synthesis is a major target within the bacterial cell for antibiotics. Investigations into
ribosome-targeting antibiotics have provided much needed functional and structural insight …
ribosome-targeting antibiotics have provided much needed functional and structural insight …
Sequence-defined transposon mutant library of Burkholderia thailandensis
LA Gallagher, E Ramage, R Patrapuvich, E Weiss… - MBio, 2013 - Am Soc Microbiol
We constructed a near-saturation transposon mutant library for Burkholderia thailandensis, a
low-virulence surrogate for the causative agent of melioidosis (Burkholderia pseudomallei) …
low-virulence surrogate for the causative agent of melioidosis (Burkholderia pseudomallei) …
Nonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals
Bacteria belonging to the genus Burkholderia live in various ecological niches and present a
significant role in the environments through the excretion of a wide variety of secondary …
significant role in the environments through the excretion of a wide variety of secondary …
Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis
While bacterial genomes typically contain numerous secondary metabolite biosynthetic
gene clusters, only a small fraction of these are expressed at any given time. The remaining …
gene clusters, only a small fraction of these are expressed at any given time. The remaining …
Discovery of novel natural products for mosquito control
Vector control plays a key role in reducing the public health burden of mosquito-borne
diseases. Today's vector control strategies largely rely on synthetic insecticides that can …
diseases. Today's vector control strategies largely rely on synthetic insecticides that can …
Genome-guided discovery of diverse natural products from Burkholderia sp.
X Liu, YQ Cheng - Journal of Industrial Microbiology and …, 2014 - academic.oup.com
Burkholderia species have emerged as a new source of diverse natural products. This mini-
review covers all of the natural products discovered in recent years from Burkholderia sp. by …
review covers all of the natural products discovered in recent years from Burkholderia sp. by …