R Dinger, C Lattermann, D Flitsch… - Biotechnology and …, 2022 - Wiley Online Library
Mini‐bioreactors with integrated online monitoring capabilities are well established in the early stages of process development. Mini‐bioreactors fulfil the demand for high‐throughput …
S Zhang, H Zheng, X Tang, C Zhao, C Zheng… - Chemical Engineering …, 2020 - Elsevier
In this study, the relationship between coagulation-flocculation and sterilization was studied using two conventional flocculants, polyaluminum chloride (PAC) and poly dimethyl diallyl …
J Pastoors, C Baltin, J Bettmer, A Deitert… - … for Biofuels and …, 2023 - Springer
Background The efficiency of downstream processes plays a crucial role in the transition from conventional petrochemical processes to sustainable biotechnological production …
H Chen, Z Chen, XQ Wang, XG Yi… - … Canadian Journal of …, 2024 - Wiley Online Library
The performance of a stirred bioreactor was evaluated in this study in terms of the bubble hydrodynamics and the mass transfer efficiency, using a non‐viscous Newtonian fluid of …
SMW Wahjudi, T Petrzik, F Oudenne… - Biotechnology …, 2023 - Wiley Online Library
Costly complex media components such as yeast extract and peptone are still widely used in industrial bioprocesses, despite their ill‐defined composition. Side stream products such …
J Müller, M Beckers, N Mußmann, J Bongaerts… - Microbial cell …, 2018 - Springer
Background Culture media containing complex compounds like yeast extract or peptone show numerous disadvantages. The chemical composition of the complex compounds is …
Process control strategies based on the physiological status of cells have recently been used to enhance mammalian cell culture productivity and robustness. In this study, we …
J Goldmanns, GA Röhling, MK Lipa, T Scholand… - BMC …, 2023 - Springer
Background One critical parameter in microbial cultivations is the composition of the cultivation medium. Nowadays, the application of chemically defined media increases, due …
N Ihling, A Uhde, R Scholz, C Schwarz… - Biotechnology …, 2020 - Wiley Online Library
Secretion of heterologous proteins into the culture supernatant in laboratory strains of Escherichia coli is possible by utilizing a Type I secretion system (T1SS). One prominent …