The proteasome is a multicatalytic proteinase complex responsible for the degradation of
most intracellular proteins, including proteins crucial to cell cycle regulation and …

The 26S proteasome constitutes the central proteolytic machinery of the highly conserved
ubiquitin/proteasome system, the cell's major tool for extralysosomal protein degradation …

Novel agents that target the proteasome, a proteolytic complex responsible for the
degradation of ubiquitinated proteins, have demonstrated remarkable therapeutic efficacy in …

Neuron death and neuron degeneration occur in the CNS during the course of aging.
Although multiple cellular alterations transpire during the aging process, those that mediate …

Protelytic enzymes are known to be associated with developmentally programmed cell
death during organ senescence and tracheary element differentiation. Recent evidence also …

The proteasome plays a pivotal role in controlling cell proliferation, apoptosis, and
differentiation in a variety of normal and tumor cells. PS-341, a novel boronic acid dipeptide …

The 26S proteasome is the key enzyme of the ubiquitin‐dependent pathway of protein
degradation. This energy‐dependent nanomachine is composed of a 20S catalytic core and …

Cancer cells frequently show high constitutive activity of the antiapoptotic transcription factor
nuclear factor κB (NF-κB), which results in their enhanced survival. Activation of NF-κB …

We explored the role of low mitochondrial membrane potential (ΔΨm) and the lack of
oxidative phosphorylation in apoptosis by assessing the susceptibility of osteosarcoma cell …

Introduction• Origin of the disease and mechanisms for neuronal death in AD–Inflammatory
reaction–Aβ‐induced neurotoxicity–Complement‐mediated neurodegeneration–Oxidative …