Dynamic modules of the coactivator SAGA in eukaryotic transcription
Abstract SAGA (Spt-Ada-Gcn5 acetyltransferase) is a highly conserved transcriptional
coactivator that consists of four functionally independent modules. Its two distinct enzymatic …
coactivator that consists of four functionally independent modules. Its two distinct enzymatic …
Sequestration of cellular interacting partners by protein aggregates: implication in a loss‐of‐function pathology
H Yang, HY Hu - The FEBS journal, 2016 - Wiley Online Library
Protein misfolding and aggregation are a hallmark of several neurodegenerative diseases
(ND s). However, how protein aggregation leads to cytotoxicity and neurodegeneration is …
(ND s). However, how protein aggregation leads to cytotoxicity and neurodegeneration is …
Challenging proteostasis: role of the chaperone network to control aggregation-prone proteins in human disease
T Sinnige, A Yu, RI Morimoto - HSF1 and Molecular Chaperones in Biology …, 2020 - Springer
Protein homeostasis (Proteostasis) is essential for correct and efficient protein function
within the living cell. Among the critical components of the Proteostasis Network (PN) are …
within the living cell. Among the critical components of the Proteostasis Network (PN) are …
A survey of protein interactions and posttranslational modifications that influence the polyglutamine diseases
The presence and aggregation of misfolded proteins has deleterious effects in the nervous
system. Among the various diseases caused by misfolded proteins is the family of the …
system. Among the various diseases caused by misfolded proteins is the family of the …
Cardiovascular disease: an introduction
M Thiriet, M Thiriet - Vasculopathies: Behavioral, Chemical, Environmental …, 2018 - Springer
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SpringerLink Account Menu Find a journal Publish with us Track your research Search Cart …
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[HTML][HTML] Molecular targets and therapeutic strategies in spinocerebellar ataxia type 7
A Niewiadomska-Cimicka, Y Trottier - Neurotherapeutics, 2019 - Elsevier
Abstract Spinocerebellar ataxia type 7 (SCA7) is a rare autosomal dominant
neurodegenerative disorder characterized by progressive neuronal loss in the cerebellum …
neurodegenerative disorder characterized by progressive neuronal loss in the cerebellum …
Ataxin‐2 sequesters Raptor into aggregates and impairs cellular mTORC1 signaling
YJ Liu, JY Wang, XL Zhang, LL Jiang… - The FEBS Journal, 2024 - Wiley Online Library
Ataxin‐2 (Atx2) is a polyglutamine (polyQ) protein, in which abnormal expansion of the
polyQ tract can trigger protein aggregation and consequently cause spinocerebellar ataxia …
polyQ tract can trigger protein aggregation and consequently cause spinocerebellar ataxia …
The Role of Protein Quantity Control in Polyglutamine Spinocerebellar Ataxias
H Zhang, X Wang - The Cerebellum, 2024 - Springer
Polyglutamine spinocerebellar ataxias (polyQ SCAs) represent the most prevalent subtype
of SCAs. The primary pathogenic mechanism is believed to be the gain-of-function …
of SCAs. The primary pathogenic mechanism is believed to be the gain-of-function …
Gene deregulation and underlying mechanisms in spinocerebellar ataxias with polyglutamine expansion
A Niewiadomska-Cimicka, A Hache… - Frontiers in …, 2020 - frontiersin.org
Polyglutamine spinocerebellar ataxias (polyQ SCAs) include SCA1, SCA2, SCA3, SCA6,
SCA7, and SCA17 and constitute a group of adult onset neurodegenerative disorders …
SCA7, and SCA17 and constitute a group of adult onset neurodegenerative disorders …
The molecular basis of spinocerebellar ataxia type 7
R Goswami, AI Bello, J Bean, KM Costanzo… - Frontiers in …, 2022 - frontiersin.org
Spinocerebellar ataxia (SCA) type 7 (SCA7) is caused by a CAG trinucleotide repeat
expansion in the ataxin 7 (ATXN7) gene, which results in polyglutamine expansion at the …
expansion in the ataxin 7 (ATXN7) gene, which results in polyglutamine expansion at the …