The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …

Abstract ATP13A2 (PARK9) is a late endolysosomal transporter that is genetically implicated
in a spectrum of neurodegenerative disorders, including Kufor-Rakeb syndrome—a …

The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Polyamines (PAs) are indispensable polycations ubiquitous to all living cells. Among their
many critical functions, PAs contribute to the oxidative balance of the cell. Beginning with …

The unease of consumers with bisphenol A has led to the increased industrial usage of
bisphenol F (BPF), which is a new hazard to environmental health. Here, zebrafish were …

Polycationic polyamines are present in nearly all living organisms and are essential for
mammalian cell growth and survival, and for development. These positively charged …

Self-nonself discrimination is vital for the immune system to mount responses against
pathogens while maintaining tolerance toward the host and innocuous commensals during …

Liver-resident macrophages (Kupffer cells, KCs) and autophagy play critical roles in the
pathogenesis of toxin-induced liver injury. Recent evidence indicates that autophagy can …