Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

The QT interval on the human electrocardiogram is normally in the order of 450 ms, and
reflects the summated durations of action potential (AP) depolarization and repolarization of …

Calmodulin (CaM) plays critical roles in cardiomyocytes, regulating Na+ (NaV) and L-type
Ca2+ channels (LTCCs). LTCC dysregulation by mutant CaMs has been implicated in action …

Alterations in cardiac electrophysiology are an established consequence of long-standing
drug resistant epilepsy. Patients with chronic epilepsy display abnormalities in both …

There is growing evidence that cardiac dysfunction in patients with chronic epilepsy could
play a pathogenic role in sudden unexpected death in epilepsy (SUDEP). Recent animal …

Ventricular arrhythmias arise from disruptions in the normal orderly sequence of electrical
activation and recovery of the heart. They can be categorized into disorders affecting …

Embryonic and larval Danio rerio (zebrafish) is increasingly used as a toxicological model to
conduct rapid in vivo tests and developmental toxicity assays; the zebrafish features high …

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related
death in patients with refractory epilepsy. Convergent lines of evidence suggest that SUDEP …

Patients with early infantile epileptic encephalopathy (EIEE) are at increased risk for sudden
unexpected death in epilepsy (SUDEP). De novo mutations of the sodium channel gene …

Objective To investigate the impact of epilepsy on secondary cardiac morbidities and
sudden death in patients with epilepsy. Patients and Methods The present cohort study …