Gene therapy and DNA delivery systems

D Ibraheem, A Elaissari, H Fessi - International journal of pharmaceutics, 2014 - Elsevier
Gene therapy is a promising new technique for treating many serious incurable diseases,
such as cancer and genetic disorders. The main problem limiting the application of this …

Acoustic behavior of microbubbles and implications for drug delivery

K Kooiman, HJ Vos, M Versluis, N De Jong - Advanced drug delivery …, 2014 - Elsevier
Ultrasound contrast agents are valuable in diagnostic ultrasound imaging, and they
increasingly show potential for drug delivery. This review focuses on the acoustic behavior …

Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery

K Ferrara, R Pollard, M Borden - Annu. Rev. Biomed. Eng., 2007 - annualreviews.org
This review offers a critical analysis of the state of the art of medical microbubbles and their
application in therapeutic delivery and monitoring. When driven by an ultrasonic pulse …

Healing sound: the use of ultrasound in drug delivery and other therapeutic applications

S Mitragotri - Nature reviews Drug discovery, 2005 - nature.com
Ultrasound, which is routinely used for diagnostic imaging applications, is now being
adopted in various drug delivery and other therapeutic applications. Ultrasound has been …

Microbubbles in ultrasound-triggered drug and gene delivery

S Hernot, AL Klibanov - Advanced drug delivery reviews, 2008 - Elsevier
Ultrasound contrast agents, in the form of gas-filled microbubbles, are becoming popular in
perfusion monitoring; they are employed as molecular imaging agents. Microbubbles are …

Microbubbles in medical imaging: current applications and future directions

JR Lindner - Nature reviews Drug discovery, 2004 - nature.com
Not all bubbles in the bloodstream are detrimental. During the past decade, contrast-
enhanced ultrasound has evolved from a purely investigational tool to a routine diagnostic …

miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-β/Smad3 signaling

Y Zhang, XR Huang, LH Wei, ACK Chung, CM Yu… - Molecular Therapy, 2014 - cell.com
Loss of miR-29 is associated with cardiac fibrosis. This study examined the role and
therapeutic potential of miR-29 in mouse model of hypertension induced by angiotensin II …

Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles

NY Rapoport, AM Kennedy, JE Shea, CL Scaife… - Journal of Controlled …, 2009 - Elsevier
The paper reports the results of nanotherapy of ovarian, breast, and pancreatic cancerous
tumors by paclitaxel-loaded nanoemulsions that convert into microbubbles locally in tumor …

[HTML][HTML] Therapeutic applications of ultrasound

G Ter Haar - Progress in biophysics and molecular biology, 2007 - Elsevier
Therapeutic applications of ultrasound predate its use in imaging. A range of biological
effects can be induced by ultrasound, depending on the exposure levels used. At low levels …

Gene therapy progress and prospects: nonviral vectors

T Niidome, L Huang - Gene therapy, 2002 - nature.com
The success of gene therapy is largely dependent on the development of the gene delivery
vector. Recently, gene transfection into target cells using naked DNA, which is a simple and …