Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

The suite of currently used drugs can be divided into two categories–traditional 'small
molecule'drugs with typical molecular weights of< 500 Da but with oral bioavailability, and …

Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

Inherent susceptibility of peptides to enzymatic degradation in the gastrointestinal tract is a
key bottleneck in oral peptide drug development. Here, we present a systematic analysis of …

Bioactive peptides have potential as drug leads, but turning them into drugs is a challenge
because of their typically poor metabolic stability. Molecular grafting is one approach to …

Introduction: An extraordinarily diverse range of animals have evolved venoms for predation,
defence, or competitor deterrence. The major components of most venoms are peptides and …

The Precision Medicine Initiative aims to use advances in basic and clinical research to
develop therapeutics that selectively target and kill cancer cells. Under the same doctrine of …

Chlorotoxin is a small 36 amino-acid peptide identified from the venom of the scorpion
Leiurus quinquestriatus. Initially, chlorotoxin was used as a pharmacological tool to …

Introduction Fluorescence-guided surgery is one of the rapidly emerging methods of surgical
“theranostics.” In this review, we summarize current fluorescence techniques used in …

The cystine knot is a structural motif that confers exceptional stability on proteins. Here we
provide an update on the topology of the cystine knot and the combinatorial diversity of …