Shape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understanding

J Sunter, K Gull - Open biology, 2017 - royalsocietypublishing.org
The shape and form of protozoan parasites are inextricably linked to their pathogenicity. The
evolutionary pressure associated with establishing and maintaining an infection and …

[HTML][HTML] Leishmania virulence factors: focus on the metalloprotease GP63

M Olivier, VD Atayde, A Isnard, K Hassani… - Microbes and infection, 2012 - Elsevier
Parasites of Leishmania genus have developed elegant strategies permitting them to evade
the innate immune response upon their initial interaction with macrophages. Their capacity …

Determinants for the development of visceral leishmaniasis disease

LI McCall, WW Zhang, G Matlashewski - PLoS pathogens, 2013 - journals.plos.org
Leishmaniasis is a vector-borne neglected tropical disease associated with a spectrum of
clinical manifestations, ranging from self-healing cutaneous lesions to fatal visceral …

Circulating microparticles: square the circle

NS Barteneva, E Fasler-Kan, M Bernimoulin, JNH Stern… - BMC cell biology, 2013 - Springer
Background The present review summarizes current knowledge about microparticles (MPs)
and provides a systematic overview of last 20 years of research on circulating MPs, with …

Leishmania exosomes and other virulence factors: Impact on innate immune response and macrophage functions

VD Atayde, K Hassani, A da Silva Lira Filho… - Cellular …, 2016 - Elsevier
Leishmania parasites are the causative agents of the leishmaniases, a collection of vector-
borne diseases that range from simple cutaneous to fatal visceral forms. Employing potent …

Exosomes and other microvesicles in infection biology: organelles with unanticipated phenotypes

JM Silverman, NE Reiner - Cellular microbiology, 2011 - Wiley Online Library
The release of exosomes and other microvesicles by diverse prokaryotic and eukaryotic
cells and organisms was first appreciated early in the 20th century. The functional properties …

Metabolic Pathways Required for the Intracellular Survival of Leishmania

MJ McConville, T Naderer - Annual review of microbiology, 2011 - annualreviews.org
Leishmania spp. are sandfly-transmitted parasitic protozoa that cause a spectrum of
important diseases and lifelong chronic infections in humans. In the mammalian host, these …

Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase

LI McCall, A El Aroussi, JY Choi, DF Vieira… - PLoS neglected …, 2015 - journals.plos.org
Leishmania protozoan parasites (Trypanosomatidae family) are the causative agents of
cutaneous, mucocutaneous and visceral leishmaniasis worldwide. While these diseases are …

Genetic Analysis of Leishmania donovani Tropism Using a Naturally Attenuated Cutaneous Strain

WW Zhang, G Ramasamy, LI McCall, A Haydock… - PLoS …, 2014 - journals.plos.org
A central question in Leishmania research is why most species cause cutaneous infections
but others cause fatal visceral disease. Interestingly, L. donovani causes both visceral and …

Virulence factors of Leishmania parasite: Their paramount importance in unraveling novel vaccine candidates and therapeutic targets

D Kumari, S Mahajan, P Kour, K Singh - Life sciences, 2022 - Elsevier
Leishmaniasis is a neglected tropical disease and remains a global concern for healthcare.
It is caused by an opportunistic protozoan parasite belonging to the genus Leishmania and …