Immunoglobulin superfamily adhesion molecules are among the most abundant proteins in
vertebrate and invertebrate nervous systems. Prominent family members are the neural cell …

Synapses are the sites of neuron-to-neuron communication and form the basis of the neural
circuits that underlie all animal cognition and behavior. Chemical synapses are specialized …

The ability to adapt to changing internal and external conditions is a key feature of biological
systems. Homeostasis refers to a regulatory process that stabilizes dynamic systems to …

The molecular biological mechanisms of Alzheimer's disease (AD) involve disease-
associated crosstalk through many genes and include a loss of normal as well as a gain of …

Retrograde signaling systems are fundamental modes of communication synapses utilize to
dynamically and adaptively modulate activity. However, the inductive mechanisms that gate …

Homeostatic signaling systems are fundamental forms of biological regulation that maintain
stable functionality in a changing environment. In the nervous system, synapses are crucial …

To identify conserved components of synapse function that are also associated with human
diseases, we conducted a genetic screen. We used the Drosophila melanogaster …

Synapses and circuits rely on neuroplasticity to adjust output and meet physiological needs.
Forms of homeostatic synaptic plasticity impart stability at synapses by countering …

Sleep is an ancient animal behavior that is regulated similarly in species ranging from flies
to humans. Various genes that regulate sleep have been identified in invertebrates, but …

Introduction: The ability of synapses to maintain physiological levels of evoked
neurotransmission is essential for neuronal stability. A variety of perturbations can disrupt …