Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Innate lymphoid cells (ILCs) functionally resemble T lymphocytes in cytotoxicity and cytokine
production but lack antigen-specific receptors, and they are important regulators of immune …

Little is known of the molecular mechanisms whereby spermatogonia, mitotic germ cells of
the testis, self-renew and differentiate into sperm,. Here we show that Zfp145, encoding the …

The cyclin-dependent kinase inhibitor p21WAF1/CIP1 is a major player in cell cycle control
and it is mainly regulated at the transcriptional level. Whereas induction of p21 …

Invariant natural killer T cells (iNKT cells) have an innate immunity–like rapidity of response
and the ability to modulate the effector functions of other cells. We show here that iNKT cells …

In response to microenvironmental signals, macrophages undergo different activation,
including the “classic” proinflammatory phenotype (also called M1), the “alternative” …

Abstract Cys2His2 (C2H2)-type zinc fingers are widespread DNA binding motifs in
eukaryotic transcription factors. Zinc fingers are short protein motifs composed of two or …

The BTB/POZ-ZF [Broad complex, Tramtrack, Bric à brac (BTB) or poxvirus and zinc finger
(POZ)-zinc finger] protein family comprises a diverse group of transcription factors. POZ-ZF …

The transcription factor c‐Myc is a key regulator of cell proliferation, cell growth,
differentiation, and apoptosis. Deregulated c‐myc expression possesses a high …