The vast majority of microbial species remain uncultivated and, until recently, about half of
all known bacterial phyla were identified only from their 16S ribosomal RNA gene sequence …

Summary Background In late December, 2019, patients presenting with viral pneumonia
due to an unidentified microbial agent were reported in Wuhan, China. A novel coronavirus …

Recent advances in single-cell genomics provide an alternative to largely gene-centric
metagenomics studies, enabling whole-genome sequencing of uncultivated bacteria …

Recent extensions of single-cell studies to multiple data modalities raise new questions
regarding experimental design. For example, the challenge of sparsity in single-omics data …

Klebsiella pneumoniae is a major threat to public health, causing significant morbidity and
mortality worldwide. The emergence of highly drug-resistant strains is particularly …

Atopic dermatitis (AD) is a multifactorial, chronic relapsing disease associated with genetic
and environmental factors. Among skin microbes, Staphylococcus aureus and …

Genomic data has revealed that genotypic variants of the same species, that is, strains,
coexist and are abundant in natural microbial communities. However, it is not clear if strains …

Chemosynthetic symbioses between bacteria and invertebrates occur worldwide from
coastal sediments to the deep sea. Most host groups are restricted to either shallow or deep …

Anelloviruses (AVs) are commensal members of the human blood virome. Even though it
was estimated that over 90% of the human population carries AVs, the dynamics of the AV …

Genetic drift is expected to remove polymorphism from populations over long periods of
time, with the rate of polymorphism loss being accelerated when species experience strong …