Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified
antigen receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells and …

Over the past decade, our view of human-associated microbes has expanded beyond that of
a few species toward an appreciation of the diverse and niche-specialized microbial …

Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell
responses, but the mechanisms controlling these distinct outcomes remain poorly …

The mutualistic relationship of gut-resident microbiota and the host immune system
promotes homeostasis that ensures maintenance of the microbial community and of a …

Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to
their unique ability to initiate T cell responses and direct their differentiation into effector …

Group 3 innate lymphoid cells (ILC3s) regulate immunity and inflammation, yet their role in
cancer remains elusive. Here, we identify that colorectal cancer (CRC) manifests with …

The gastrointestinal microbiome is a diverse consortium of bacteria, archaea, fungi,
protozoa, and viruses that inhabit the gut of all mammals. Studies in humans and other …

The microbiota plays a fundamental role in the induction, education, and function of the host
immune system. In return, the host immune system has evolved multiple means by which to …

The intestinal microbiome is a signalling hub that integrates environmental inputs, such as
diet, with genetic and immune signals to affect the host's metabolism, immunity and …

Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can …