The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Abstract Fibroblast growth factor 8 (FGF‐8), also known as androgen‐induced growth factor
(AIGF), is presumed to be a potent mitogenic cytokine that plays important roles in early …

Limb regeneration is a frontier in biomedical science. Identifying triggers of innate
morphogenetic responses in vivo to induce the growth of healthy patterned tissue would …

Loss of regenerative capacity is a normal part of aging. However, some organisms, such as
the Mexican axolotl, retain striking regenerative capacity throughout their lives. Moreover …

An effective healing response is critical to promote and ensure healthy aging. Major
discoveries in both fields—repair and aging—have led to a better understanding of the …

Tendons are cable-like connective tissues that transfer both active and passive forces
generated by skeletal muscle to bone. In the mature skeleton, the tendon-bone enthesis is …

The mechanisms that regulate growth and size of the regenerating limb in tetrapods such as
the Mexican axolotl are unknown. Upon the completion of the developmental stages of …

Throughout the animal kingdom regenerative ability varies greatly from species to species,
and even tissue to tissue within the same organism. The sheer diversity of structures and …

Introduction: Little is known about how the newly regenerated limb tissues in the Mexican
axolotl seamlessly integrate with the remaining stump tissues to form a functional structure …

Bone morphogenetic proteins (BMPs) are a highly conserved and diverse family of proteins
that play essential roles in various stages of development including the formation and …