Proteins tendency to bind to one another in a highly specific manner forming stable
complexes is fundamental to all biological processes. A better understanding of complex …

Protein–protein binding is one of the critical events in biology, and knowledge of proteic
complexes three‐dimensional structures is of fundamental importance for the biochemical …

The crucial prerequisite for proper biological function is the protein's ability to establish
highly selective interactions with macromolecular partners. A missense mutation that alters …

Angiogenesis, or formation of new blood capillaries from preexisting vessels, plays both
beneficial and damaging roles in the organism. It is a result of a complex balance of positive …

Recognition by the T‐cell receptor (TCR) of immunogenic peptides (p) presented by class I
major histocompatibility complexes (MHC) is the key event in the immune response against …

Abstract Knowledge of protein-protein interaction sites provides an important base for
deciphering novel drug targets and applications of enzyme-based studies. But on account of …

Understanding protein–protein association and being able to determine the crucial residues
responsible for their association (hot-spots) is a key issue with huge practical applications …

Substitution mutations in protein–protein interfaces can have a substantial effect on binding,
which has consequences in basic and applied biomedical research. Experimental …

The central role of protein–protein interactions in a wide range of cellular processes makes
them a target for research and drug discovery. A variety of methods, both experimental and …

A novel acute viral pneumonia induced by SARS-CoV-2 exploded at the end of 2019,
causing a severe medical and economic crisis. For developing specific pharmacotherapy …