Aminoglycoside antibiotics were among the first antibiotics discovered and used clinically.
Although they have never completely fallen out of favor, their importance has waned due to …

Hereunder, we highlight bacterial membrane anionic lipids as attractive targets in the design
of antibacterial drugs which can be effective against both Gram-positive and Gram-negative …

Shortly after the discovery of the first antibiotics, bacterial resistance began to emerge. Many
mechanisms give rise to resistance; the most prevalent mechanism of resistance to the …

Decades of widespread clinical use of the bacterial ribosomeA-site-targeting
aminoglycosides (AGs) enhanced the evolution of resistance to these antibiotics and …

Cationic amphiphiles derived from aminoglycosides (AGs) have been shown to exhibit
enhanced antimicrobial activity. Through the attachment of hydrophobic residues such as …

Despite their clinical importance, saving numerous human lifes, over-and mis-uses of
antibiotics have created a strong selective pressure on bacteria, which induces the …

Since the discovery of the first aminoglycoside (AG), streptomycin, in 1943, these broad-
spectrum antibiotics have been extensively used for the treatment of Gram-negative and …

Aminoglycosides are a class of antibiotics with a broad spectrum of antimicrobial activity.
Unfortunately, resistance in clinical isolates is pervasive, rendering many aminoglycosides …

Aminoglycosides are the most preferred choice of therapy against serious infections in
humans. Therefore, its use in animal husbandry has been strictly regulated in the EU, UK …

Aminoglycosides (AGs) constitute a major family of potent and broad-spectrum antibiotics
disturbing protein synthesis through binding to the A site of 16S rRNA. Decades of …